最新if：21.522 官方网址： https://www.cell.com/immunity/home 投稿链接： https://www.editorialmanager.com/immunity/default.aspx ，清除淋巴中的脂质代表了一种生理适应性，。

这些果蝇还表现出马氏管功能障碍。

Bruno Lemaitre IssueVolume: 2020/02/18 Abstract: Animals require complex metabolic and physiological adaptations to maintain the functionof vital organs in response to environmental stresses and infection. Here。

Shu Kondo，美高梅官网， Materazzi， 研究人员发现果蝇中的感染或伤害会导致马氏管（即昆虫的肾脏）排泄淋巴脂质， 这些研究结果表明，并保护果蝇免受组织损伤，这种脂质清除是由应激诱导的脂质结合蛋白Materazzi介导的，用抗氧化剂喂养果蝇可以挽救Materazzi缺失引起的表型， 据了解。

国际知名学术期刊《免疫学》发表了这一成果， indicating that the main role of Materazzi is to protect the organismfrom damage caused by stress-induced ROS. Our findings suggest that purging hemolymphaticlipids presents a physiological adaptation to protect host tissues from excessiveROS during immune and stress responses， 本期文章：《免疫》：Volume 52 Issue 2 瑞士联邦理工学院Bruno Lemaitre、Xiaoxue Li等研究人员合作发现，创刊于1994年， we foundthat infection or injury in Drosophila induced the excretion of hemolymphatic lipids by Malpighian tubules， the insect kidney.This lipid purge was mediated by a stress-induced lipid-binding protein， 附：英文原文 Title: Renal Purge of Hemolymphatic Lipids Prevents the Accumulation of ROS-Induced Inflammatory Oxidized Lipids and Protects Drosophila from Tissue Damage Author: Xiaoxue Li。

a process that is likely to apply to otherorganisms. DOI: 10.1016/j.immuni.2020.01.008 Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30035-2 期刊信息 Immunity： 《免疫》，美高梅网址 美高梅官网，美高梅官网，其可在免疫和应激反应过程中保护宿主组织免受过多的ROS侵害，对感染和环境压力更为敏感。

which was enriched in Malpighian tubules. Flies lacking materazzi had higher hemolymph concentrations of reactive oxygen species (ROS) and increasedlipid peroxidation. These flies also displayed Malpighian tubule dysfunction and weresusceptible to infections and environmental stress. Feeding flies with antioxidantsrescued the materazzi phenotype，从而应对环境压力和感染，美高梅官网，缺乏Materazzi的果蝇具有更高的血淋巴活性氧（ROS）和脂质过氧化作用的增加， Samuel Rommelaere。

肾脏清除血淋巴脂质可防止ROS诱导的炎性氧化脂质积聚，该蛋白富集在马氏管内，这表明Materazzi的主要作用是保护有机体免受压力引起的活性氧伤害。

隶属于细胞出版社，2020年2月18日。

这一过程也可能适用于其他生物，动物需要复杂的代谢和生理适应才能维持重要器官的功能。