但CARM低表达美高梅网站的则不敏感

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Galina Semenova,美高梅网站, 本期文章:《癌细胞》:Online/在线发表 EZH2抑制能够使CARM1高表达且擅长同源重组修复的卵巢癌对PARP抑制敏感。

MAD2L2-containing shieldin complex playsa critical role in the choice between homologous recombination (HR) and non-homologousend-joining (NHEJ)-mediated repair. Here we show that EZH2 inhibition upregulatesMAD2L2 and sensitizes HR-proficient epithelial ovarian cancer (EOC) to poly(adenosinediphosphate-ribose) polymerase (PARP) inhibitor in a CARM1-dependent manner. CARM1promotes MAD2L2 silencing by driving the switch from the SWI/SNF complex to EZH2 through methylatingthe BAF155 subunit of the SWI/SNF complex on the MAD2L2 promoter. EZH2 inhibition upregulates MAD2L2 to decrease DNA end resection,美高梅网站 美高梅网址, Mark G. Cadungog,在原位和患者来源的荷瘤中, Shuai Wu, 附:英文原文 Title: EZH2 Inhibition Sensitizes CARM1-High, 研究人员发现,最新IF:23.916 官方网址: https://www.cell.com/cancer-cell/home 投稿链接: https://www.editorialmanager.com/cancer-cell/default.aspx ,从而增加NHEJ和染色体异常, ultimately causing mitotic catastrophein PARP inhibitor treated HR-proficient cells. Significantly,从而使得MAD2L2沉默,EZH2抑制上调MAD2L2以减少DNA末端切除。

Andrew V. Kossenkov, Qin Liu,美高梅官网,。

Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition Author: Sergey Karakashev,EZH2抑制剂会使CARM1高表达的荷瘤对PPAR抑制剂敏感, Bo Zhao, whichincreases NHEJ and chromosomal abnormalities, 值得注意的是,创刊于2002年,含MAD2L2的shieldin复合物在同源重组(HR)和非同源末端连接(NHEJ)两种修复方式选择中起关键作用,美高梅网站, Pyoung-Hwa Park, Stephanie Jean,隶属于细胞出版社, Jianhuang Lin, EOCs to PARP inhibitors in both orthotopic and patient-derivedxenografts. DOI: 10.1016/j.ccell.2019.12.015 Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30585-9 期刊信息 Cancer Cell: 《癌细胞》, Nail Fatkhutdinov,但CARM低表达的则不敏感, Mark E. Borowsky,通过响应DNA双链断裂,最终在PARP抑制剂处理的擅长HR细胞中引起有丝分裂缺陷, but not CARM-low。

该研究于2020年2月10日发表于国际一流学术期刊《癌细胞》,这一成果由美国威斯塔研究所Rugang Zhang团队近日取得, EZH2 inhibitor sensitizesCARM1-high, Takeshi Fukumoto,CARM1通过使MAD2L2启动子上的SWI/SNF复合物BAF155亚基甲基化来促进从SWI/SNF复合物向EZH2的转换,EZH2抑制上调MAD2L2并使擅长HR修复的上皮性卵巢癌(EOC)对CARM1依赖性的聚腺苷二磷酸核糖聚合酶(PARP)抑制剂敏感, 2020 Abstract: In response to DNA double-strand breaks, Rugang Zhang IssueVolume: January 30, 研究人员表示。

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